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Hypertension & Diabetes

Blood pressure is the force of blood against your blood vessels as it circulates. This force is necessary to make the blood flow, delivering nutrients and oxygen throughout your body. High blood pressure, also called hypertension, means there is too much pressure in your blood vessels. It may precede the onset of diabetes mellitus (DM). In many of the cases, both hypertension and diabetes mellitus may be diagnosed together. Diabetic population has almost doubled occurrence of hypertension as compared to non-diabetic general population.

Diabetes and high blood pressure are considered as major cardiovascular risk factors, which mean these can lead to coronary artery disease, stroke, left ventricular hypertrophy, and nephropathy. Patients suffering from both diabetes and high blood pressure have greater risk of atherosclerosis.

What are causes of high blood pressure?2

Are you diagnosed with blood pressure & diabetes?

If yes, then monitor yourself regularly

Learn how to measure blood pressure & blood sugar at home, keep record of these.

What are the recommendations for starting anti-hypertensives?

British Hypertension Society, British Hyperlipidaemia Association and British Cardiac Society have jointly suggested the initiations of treatment of hypertension in diabetics when BP is equal to or more than 140/90 mm Hg. According to the WHO Expert Committee Recommendation in Hypertension Control treatment may be instituted at BP 130/85 mm Hg in a patient with diabetic nephropathy

Are lifestyle modifications recommended for Diabetic hypertensives?

Lifestyle modifications are must for diabetic hypertensive patients. These modifications also correct obesity, hyperglycaemia, hyperinsulinaemia, and act as primary prevention against cardiovascular risks. These will reduce blood pressure and control blood glucose levels.

Regular physical activity

It has been observed that regular physical activity has an independent cardioprotective effect.  Regular aerobic exercise can reduce systolic BP by an average of 4 mmHg and diastolic BP by an average of 2.5 mmHg. It is advised to all patients to become physically active, as part of a comprehensive plan to control hypertension and diabetes, regardless of drug treatment. Aim for 30 minutes of moderate-intensity physical activity on most, if not all, days of the week.

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Quitting smoking

Quitting smoking may not directly reduce BP, but markedly reduces overall cardiovascular risk. The risk of myocardial infarction is 2–6 times higher and the risk of stroke is 3 times higher in people who smoke than in non-smokers.

Quitting smoking also helps in better management of blood glucose and HbA1c levels.4

Dietary Modification

Adequate intake of dietary-fibre, and K+, Ca++, Mg++ from fresh fruit, green vegetables, and dairy products should be ensured. Mg++ is provided by chlorophyll of green leafy vegetables. Anti-obesity diet should not contain more than 1/3rd of total calories from fat. Of the fat calories, 1/3rd should be derived from saturated fat and 2/3 from poly- or monounsaturated fat.

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Weight reduction

Every 1% reduction in body weight lowers systolic BP by an average of 1 mmHg. Weight reduction by as little as 4.5 kg reduces BP and/or prevents hypertension in a large proportion of overweight people. Weight loss of 10 kg can reduce systolic BP by 6–10 mmHg.

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Reducing Alcohol Intake

Reducing alcohol intake may reduce BP in many patients and also contributes in better management of blood sugar levels.

Co-existence of diabetes mellitus and hypertension increases the risk of macro – and micro-vascular complications. Blood pressure should be measured in supine, sitting, and standing postures in a diabetic patient to detect existence of autonomic neuropathy and drug induced postural hypotension. A good BP control (130/80 or below) prevents or retards the progress of both micro and macro-vascular complications. Tight control of blood glucose levels prevents or delays the progress of micro-vascular complications.

It is very important and must of diabetic hypertensive patients to modify their lifestyle to lead a healthy and happy life.

FenfuroTM is a clinically evaluated dietary supplement for effective management of blood glucose levels. It is supported by 6 international patents.

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References

 

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Metformin Contraindications & Benefits from Fenugreek

Manage your Blood glucose levels.

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METFORMIN

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Introduction

  • Metformin is the first-line medication for type-2 diabetes to control blood sugar levels. It is also used in the treatment of polycystic ovary syndrome (PCOS).
  • It is an “insulin sensitizer” which means that it works to make the cells in the body more receptive to insulin.
  • When the cells are insulin sensitive, they are able to take more glucose from the blood to be used for energy.

(http://www.diabetesselfmanagement.com/blog/diabetes-medicine-metformin/)

Mechanism of action

  • It lowers the blood sugar levels in type-2 diabetic patients by decreasing the amount of glucose released into the blood stream by the liver. Thus, it lowers the glucose production by liver.
  • In type-2 diabetic patients, the glucose production by liver is 3-times more than a normal individual. Metformin reduces this by one-third.

(Kirpichnikov D et al.: Metformin: an update. Ann Intern Med. 2002; 137(1):25-33)

Contraindications

Metformin is generally well tolerated but it has some side effects such as:

glucophage_contraindications

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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  • Metformin is a widely used anti-diabetic drug. Deterioration of sleep is an important unwanted side effect of metformin. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354927/)
  • Lactic acidosis: Most serious side effect caused by metformin is lactic acidosis. Lactic acidosis happens when there is not enough oxygen in the body and too much lactic acid builds up in the blood. Dehydration and drinking large amounts of alcohol can bring on lactic acidosis. Metformin also worsens this state of lactic acidosis. Its symptoms include:
    • Muscle pain
    • Numbness in the arms & legs
    • Trouble breathing
    • Stomach pain
    • Feeling very weak or dizzy
    • Slow or uneven heart rate
    • Nausea with vomiting
  • U. S. Food and Drug Administration (FDA) gave safety announcement regarding metformin use by kidney patients. According to FDA, metformin increases the risk of developing a serious and potentially deadly condition called lactic acidosis in kidney patients consuming metformin.

(https://www.drugs.com/metformin.html)

(Kim M J et al.: Metformin-associated lactic acidosis:predisposing, factors and outcome. Endocrinol Metab 2015; 30:78-83)

(http://www.fda.gov/Drugs/DrugSafety/ucm493244.htm)

Other general reported side effects

  • Minor side effects including diarrhea, nausea and abdominal pain.
  • Metformin does not signal the pancreas to release insulin due to which there is a little risk of low blood sugar (hypoglycemia) when taking this drug.
  • Decreased appetite
  • Heart burn

  

Are you on Metformin for a long time, then answering following five questions is very important

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  1. Do you feel muscle pain?

  2. Do you feel numbness in your arms & legs?

  3. Do you feel weakness or dizziness?

  4. Do you have sleep disorder?

  5. Is there change in your diet?

 

If YES Consult Your Doctor

 

FENUGREEK & DIABETES MANAGEMENT

download (1)

  • Research and traditional usage suggests that Fenugreek seeds (Trigonella foenum graecum) are among the best in terms of safety and efficacy. According to the clinical studies, seeds of Fenugreek are a rich source of fiber and have multiple benefits in patients with diabetes.
  • Mechanism: Soluble fiber in fenugreek seeds helps to lower blood sugar by slowing down carbohydrate digestion & absorption and stimulate insulin.
  • Blood sugar: Animal research suggests that fenugreek may also contain a substance that stimulates insulin production and improves blood sugar control. The bioactive components responsible for anti-diabetic activity of fenugreek are soluble fiber, alkaloids and amino acids. Soluble fibers delay the intestinal absorption of ingested sugar. 4-hydroxyisoleucine amino acid acts on pancreas to increase the release of insulin from islets of Langerhans. Thus, the risk of hypoglycemia, as in the case of metformin consumption, never originates while consuming fenugreek.

(http://www.botanical-online.com/english/fenugreek_diabetes.htm)

OTHER HEALTH BENEFITS

(http://www.uofmhealth.org/health-library/hn-2090006)

  • Inflammation, gastrointestinal problems and muscle pain: Abebe W also suggested that fenugreek is indicated for inflammation, gastrointestinal problems and muscle pain. The bioactive components responsible for this activity of fenugreek include alkaloids, saponins, amino acids etc. These bioactive components contribute to the anti-inflammatory and anti-oxidant property of fenugreek.
  • Cholesterol & heart conditions: Incorporation of fenugreek in the regular diet can promote healthy cholesterol levels and play a role in the treatment of heart conditions like atherosclerosis, also known as “hardening of the arteries.”

(http://www.evitamins.com/a/10-best-uses-fenugreek-452)

  • Appetite: In case of metformin consumption, there is decrease in appetite but while consuming fenugreek, the appetite gets balanced because it increases the production of bile by the liver.

(http://www.fenugreekworld.com/fenugreek-and-fennel-seeds-for-increasing-the-appetite-in-kids/)

  • Heartburn: Fenugreek can be an effective remedy for acid reflux orheartburn. Mucilage of fenugreek seeds coat the lining of the stomach and intestine and soothe irritated gastrointestinal tissues.

(http://www.thehealthsite.com/diseases-conditions/15-health-benefits-of-methi/)

  • Vitamins: It is also rich in many vital vitamins that are essential nutrients for optimum health, including thiamin, pyridoxine (vitamin B6), folic acid, riboflavin, niacin, vitamin A, and vitamin-C.
  • Minerals: Fenugreek is an excellent sources of minerals likecopper, potassium, calcium, iron, selenium, zinc, manganese, and magnesium. Potassium is an important component of cell and body fluids that helps control heart rate and blood pressure by countering action on sodium. Iron is essential for red blood cell production and as a co-factor for cytochrome-oxidases enzymes.

 

FenfuroTM is a patented and clinically evaluated product for safe and effective management of blood sugar levels. Fenfuro is a first of its kind, safe nutraceutical derived from fenugreek seeds through a patented process. Through its unique scientific process, FENFURO concentrates the bioactive part of plants into a manageable dose, while removing the inert parts such as cellulose. Also, since a lot of healthy botanicals are not palatable, consuming their concentrate in capsule form in small dosage is a lot easier. FENFURO contains a rich variety of saponins and flavonoids. These substances are known to lower blood lipid level and help in insulin sensitization and glucose regulation. FENFURO is the first dual action insulin sensitizer.

A clinical evaluation of FENFURO was carried out on a total of 154 Type 2 diabetics for a period of 3 months, to determine its efficacy and safety. At the end of three months 83% of the patients reported decrease in fasting sugar levels and89% patients reported decrease in PP sugar levels. The patients also showed significant decrease in HbA1C levels as compared to respective baseline value. 48.8% of patients reported reduction in dosage of anti-diabetic therapy after regularly taking FENFURO.

 

References

  • Wulffele MG, Kooy A, Lehert P, Bets D, Ogterop JC, Borger van der Burg B, Donker AJ, Stehouwer CD.Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med. November 2003;254(5):455–63
  • Gupta A, Gupta R and Lal B: Effect of Trigonella foenum graecum seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: A double blind placebo controlled study. J Assoc Physicians India 2001; 49:1057-1061
  • Abebe W: Herbal medication: potential for adverse interactions with analgesic drugs. Journal of Clinical Pharmacy and Therapeutics 2002; 27:391–40.
  • Mahajan R, Gupta K. Revisiting Metformin: Annual Vitamin B12 Supplementation may become Mandatory with Long-Term Metformin Use. J Young Pharm. 2010Oct;2(4):428-9. doi: 10.4103/0975-1483.71621. PubMed PMID: 21264109; PubMedCentral PMCID: PMC3019388.

 

 

 

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Signs of High and Low Blood Sugar

 

One of the challenges of managing diabetes is maintaining consistent blood sugar (glucose) levels. Even with diligence, some situations can cause high blood sugar, or hyperglycemia, while others can bring on low blood sugar, or hypoglycemia.

There’s a lot you can do to minimize blood sugar ups and downs andavoid complications by monitoring your blood sugar levels with a glucose meter. How often to test depends on many factors, including the type of diabetes you have, any complications you’re facing, and the therapies you’re on, says Amber Taylor, MD, director of diabetes at the Center for Endocrinology at Mercy Hospital in Baltimore, Md.

It’s also important to know the signs of both high blood sugar and low blood sugar, and what actions to take to bring blood sugar levels back to a desired range.

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About High Blood Sugar (Hyperglycemia)

Common signs of high blood sugar include frequent urination, feeling thirsty, eating more food but not gaining as much weight as usual, fatigue, dry or itchy skin, and more frequent infections, says Athena Philis-Tsimikas, MD of the Scripps Whittier Diabetes Institute in La Jolla, Calif.

A blood sugar reading above 180 milligrams per deciliter (mg/dL) is considered above normal and can bring on these symptoms, although it’s possible to have high blood sugar without any symptoms, Dr. Philis-Tsimikas says. A reading above 300 mg/dL is considered severe. If your blood sugar is above 250 mg/dL for two days, Philis-Tsimikas advises informing your doctor and asking for specific recommendations for treatment. Having blood sugar levels above 300 mg/dL for more than a week can lead to more severe symptoms such as nausea, drowsiness, blurred vision, confusion, and dizziness, especially when standing up from a sitting or lying position.

Ways to treat high blood sugar include:

  • Taking your prescribed medications as directed
  • Eating fewer carbohydrates with your meals
  • Exercising regularly with your doctor’s guidance

About Low Blood Sugar (Hypoglycemia)

When your blood sugar drops rapidly or when the reading falls between 50 to 70 mg/dL if you take medications for diabetes, Philis-Tsimikas says you may experience early symptoms of low blood sugar such as shaking, sweating, rapid heartbeat, headache, hunger, weakness, fatigue, impaired vision, anxiety, irritability, and dizziness.

Blood sugar values that drop below 50 mg/dL are considered severe and can lead to more significant and dangerous symptoms such as difficulty concentrating, confusion, loss of consciousness, and seizures. If you experience more than two blood sugar readings below 50 mg/dL in a week, notify your doctor and go over your treatment plan.

To treat blood sugar below 70 mg/dL, Philis-Tsimikas recommends ONE of these options:

  • Drink one-half to one cup of juice, skim milk, or regular soda OR
  • Chew five to six hard candies OR
  • Take four glucose tablets OR
  • Swallow one tube of glucose gel

Then, check your blood sugar in 15 minutes. If it’s still below 70 mg/dL, eat more sugar. If your symptoms don’t stop, call your doctor or seek medical attention. If your blood sugar returns to normal, be sure to eat at your next scheduled meal or snack.

Use Supplement for Diabetes: 

FENFURO Regular intake of FENFURO can control the blood sugar level effectively. FENFURO is a first of its kind, safe nutraceutical derived from fenugreek seeds through a patented process.  Through its unique scientific process, FENFURO concentrates the bioactive part of plants into a manageable dose, while removing the inert parts such as cellulose. Also, since a lot of healthy botanicals are not palatable, consuming their concentrate in capsule form in small dosage is a lot easier. FENFURO contains a rich variety of saponins and flavonoids. These substances are known to lower blood lipid level and help in insulin sensitization and glucose regulation. FENFURO is the first dual action insulin sensitizer.

The statement and product have not been evaluated by the FDA to diagnose, treat, cure or prevent any disease.

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Type 2 Diabetes and Sleep Troubles

Sleep is important for everyone, but it’s especially important when your body experiences changing blood sugar levels and other symptoms of type 2 diabetes. “Sleep deprivation causes changes in the effectiveness of the body’s control of appetite, which can lead to weight gain, higher blood sugar, and increased resistance to insulin,” says Richard Castriotta, MD, director of the division of pulmonary, critical care, and sleep medicine at the University of Texas Health Science Center at Houston. 

Although sleep is very important when you have type 2 diabetes, you may find you can’t sleep when you need it most. One explanation for the problem seems to be the connection between diabetes and sleep apnea. Sleep apnea is a condition that’s characterized by periods of halted breathing while you’re asleep, which wakes you up repeatedly throughout the night, leaving you fatigued and not well rested in the morning.

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Both type 2 diabetes and sleep apnea are health concerns that are linked to obesity, so experts have long recognized a connection between the two. However, only recently has it been realized how closely these conditions are tied to one another. “There’s much more interrelation between the two conditions than we thought,” says Betul Hatipoglu, MD, a physician in the Cleveland Clinic’s department of endocrinology, diabetes, and metabolism. “In fact, one may actually contribute to causing the other, and vice versa. Recent studies have shown that sleep apnea actually increases insulin resistance, hunger, and other type 2 diabetes symptoms,” Dr. Hatipoglu says. “Other studies have shown that treating sleep apnea also improves the symptoms of type 2 diabetes.”

Other Sleep Issues You Might Face 

Another problem that disrupts sleep is frequent urination, a common symptom of type 2 diabetes. You can’t sleep if you have to keep getting up to go to the bathroom. Hatipoglu says this problem is usually tied to high blood pressure, which is also common with type 2 diabetes. As your blood pressure goes up throughout the night, the need to urinate increases. “If this occurs more than once a night, we view it as an issue that needs to be treated,” Hatipoglu says.

Having type 2 diabetes may also lead to other disorders that make it harder to sleep. “In addition to sleep apnea, people with type 2 diabetes are at increased risk for restless leg syndrome (RLS) and periodic limb movements in sleep (PLMS), as well as neuropathy and pain-associated sleep disruption,” Dr. Castriotta says. “RLS causes difficulty falling asleep because of strange feelings in the legs beginning in the evening before sleep. PLMS may cause either sleep-maintenance insomnia (difficulty staying asleep) or a feeling of non-refreshing sleep and daytime sleepiness due to slow, rhythmic limb movements during sleep.”

Tips to Get a Good Night’s Sleep

The first step in managing your sleep problems with type 2 diabetes is to see a doctor or a sleep specialist. Sleep apnea is a serious, potentially life-threatening problem that needs medical attention to remedy. Frequent urination and other sleep-depriving issues should also be treated by a medical professional.

In addition to talking to your doctor and seeing a sleep specialist, here are some additional strategies that may help you sleep:

Reduce your caffeine intake: Caffeinated beverages can keep you up at night and increase the urge to urinate throughout the night. If you can’t cut caffeine out entirely, Hatipoglu recommends to at least eliminate your intake in the afternoon and evening.

Curb the use of electronics in the bedroom: Television is a no-no in the bedroom, as it will keep you up when you need to be focusing on resting. Watch TV in another room, and turn it off at least an hour before you want to nod off. Try reading a book or listening to relaxing music instead.

Keep your bedroom cool, dark, and calm: Removing all light from the room, using light-blocking curtains, and outfitting your bed with appropriate bedding helps to create an atmosphere that is conducive to sleep.

Create a regular bedtime schedule: Hatipoglu says you need to train your body to get a good night’s sleep. One of the most important ways you can do this is to create a scheduled bedtime and stick to it as closely as possible each night. You can incorporate things into this routine that get your body ready for bed, such as having a few sips of relaxing chamomile tea, meditating, or doing deep breathing exercises before you close your eyes.

Sleep issues are a troubling side effect of type 2 diabetes that can leave you feeling tired all the time. By taking these steps and working with your medical team, you should be able to have sweet dreams every night.

Use Supplement for Blood sugar

FENFURO Regular intake of FENFURO can control the blood sugar level effectively. FENFURO is a first of its kind, safe nutraceutical derived from fenugreek seeds through a patented process.  Through its unique scientific process, FENFURO concentrates the bioactive part of plants into a manageable dose, while removing the inert parts such as cellulose. Also, since a lot of healthy botanicals are not palatable, consuming their concentrate in capsule form in small dosage is a lot easier. FENFURO contains a rich variety of saponins and flavonoids. These substances are known to lower blood lipid level and help in insulin sensitization and glucose regulation. FENFURO is the first dual action insulin sensitizer.

The statement and product have not been evaluated by the FDA to diagnose, treat, cure or prevent any disease.

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10 Things Only a Diabetic would understand

  1. You have a space in your home dedicated to diabetes supplies

            Image 1

  1. Being high means something completely different to you.

            Image 2

  1. You can calculate insulin on board, carb factors, insulin to carb ratio without hesitation.

            Image 3

  1. Everyone wants to know why you use a pager.

           Image 4

  1. You have cases of juice boxes stashed in your house but they aren’t for the apocalypse.

            Image 5

  1. The pharmacist is a contact in your phone and you both know each other by name.

            Image 6

  1. Your fridge has never seen a stick of butter. The compartment is used for storing insulin.

            Image 7

      8. You’re constantly offered sugar-free food that’s full of carbohydrates.

            Image 8

  1. You click on articles that claim to help you improve glucose levels, only to find an article about prevention. Image 9
  2. You’ve been offered countless diabetes home remedies from friends and relatives. Seriously, why do people do this?

         Image 10

Fenfuro is a leading provider of Fenugreek seed extract, which is growing in popularity as both a super food and an effective home remedy for diabetes. Studies suggest that fenugreek seed extract contains properties that can lower cholesterol and blood sugar. FENFURO, a group of furostanolic saponins derived from fenugreek seeds, contains a rich variety of saponins and flavonoids, all substances known to lower blood lipid levels and play valuable role in glucose regulation. Fenfuro is patented and clinically evaluated. For more information, visit www.fenfuro.com.

 

The statement and product mentioned in this article have not been evaluated by the FDA to diagnose, treat, cure or prevent any disease.

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High Blood Glucose and obesity link to cancer

 

High Blood Glucose and obesity could make a person more vulnerable to certain types of cancers and the best way to counter the threat is to lose weight.

obesity-diabetes

High Blood Glucose and obesity are associated with some types of cancer, including that of the pancreas, oesophagus and breast,” said Edwin Gale, professor of diabetes at Bristol University‘s division of medicine. He was in the city to address a conference organised byIntegrated Diabetes and Endocrinology Academy (Idea), Calcutta.

According to Gale, 40 per cent of these cancers are apparently caused by diabetes and obesity. “High Blood Glucose and obesity leads to insulin resistance in the body that can cause cancer. The best way to reduce insulin resistance is weight loss,” he explained.

Insulin resistance is a physiological condition, where the hormone becomes less effective at lowering blood sugar. This might increase blood glucose levels above the normal range.

“Fat and muscle cells need insulin to absorb glucose. But in an insulin-resistant person, these cells fail to adequately respond to circulate insulin and blood glucose levels rise,” said a doctor at the conference.

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Gale said an obese person had a 30 per cent increased risk of suffering from cancer than a person of normal weight.

“An obese person with blood sugar is more susceptible to cancer than one who is not. Although the exact cause is not clear, the common belief is that insulin resistance is the underlying factor,” said Subhankar Chowdhury, head of endocrinology, SSKM Hospital.

Use Supplement for blood sugar

FENFURO Regular intake of FENFURO can control the blood sugar level effectively. FENFURO is a first of its kind, safe nutraceutical derived from fenugreek seeds through a patented process.  Through its unique scientific process, FENFURO concentrates the bioactive part of plants into a manageable dose, while removing the inert parts such as cellulose. Also, since a lot of healthy botanicals are not palatable, consuming their concentrate in capsule form in small dosage is a lot easier. FENFURO contains a rich variety of saponins and flavonoids. These substances are known to lower blood lipid level and help in insulin sensitization and glucose regulation. FENFURO is the first dual action insulin sensitizer.

The statement and product have not been evaluated by the FDA to diagnose, treat, cure or prevent any disease.