ANTIOXIDANTS – Chereso Health

HEALTH BENEFITS OF GREEN COFFEE BEANS

Green Coffee is derived from unrefined and unroasted seeds or beans from the popular Coffee fruit. The green coffee bean extract is proven to show miraculous health benefits especially in weight loss. It is gaining popularity as more & more research work is proving the HEALTH BENEFITS OF GREEN COFFEE BEANS.

Green coffee beans extract vs black coffee

While most of its health benefits are due to the presence of its major component, namely, chlorogenic acid, there are other HEALTH BENEFITS OF GREEN COFFEE BEANS which are because of some other compounds and factors. While the green coffee beans are in the natural state, the black coffee beans are roasted. Chlorogenic Acid is believed to be the main active component in green coffee beans but most part of the chlorogenic acids are destroyed when coffee is roasted Unlike green coffee beans, caffeine is present in a far greater percentage in black coffee, and the content of chlorogenic acids is lowered to 7% of the total bean weight.

How it works

It has been reported that the green coffee bean extract has a comparatively higher degree of absorption. Once green coffee bean extract is consumed, half the chlorogenic acid is quickly metabolized into caffeinated and ferulic acid, a very small percentage continues to function in the body in the original form, i.e CGA. The metabolism rate differs in individuals, but chlorogenic acid and its metabolites are detected in the body even 24 hours after administration. The other half is metabolized into benzoic (hippuric) acid.

The three major metabolites are responsible for the majority of HEALTH BENEFITS OF GREEN COFFEE BEANS.

Proven HEALTH BENEFITS OF GREEN COFFEE BEANS Extract

Green Coffee for Weight Loss

A study published in BMC Complementary and Alternative Medicine in march 2006 has stated that the daily consumption of green coffee bean capsules or extract in any form comparatively reduces the body fat as well as the fat composition present in the liver. The same experiment was conducted on other group using only the isolated chlorogenic acids and caffeine and the results were same. Thus, it was concluded that Chlorogenic Acids present in a green coffee bean can help in losing weight.

Reduces Risk of Diabetes

Regular consumption of green coffee beans extract reduces the risk of type 2 diabetes mellitus (T2DM), and CGA is major bioactive compound in coffee that provides health benefits. It has been reported that daily consumption of 3 to 4 cups of decaffeinated coffee containing high percentage of CGA significantly reduces the risk for T2DM by 30% . Chlorogenic acid (CGA) is a great insulin sensitizer that improves the
insulin action. It had been reported that Chlorogenic acid (CGA) at a dose of 5 mg/kg body weight exerts antidiabetic effect in nicotinamide induced diabetic rats.

CGA is reported to attenuate intestinal glucose absorption, indicating a possible role for CGA as a glycaemic index lowering agent as well as helps in reducing the risk of developing T2DM.

It was reported that consuming CGA significantly reduced early fasting glucose and insulin responses in overweight men during an oral glucose tolerance test.

Many Clinical trials establish that Chlorogenic Acid in coffee is able to harmonize glucose intake and gastrointestinal hormone and insulin secretion in humans.

Reduces Risk of Heart Disease

Hypercholesterolemia is a major risk factor for the advancement of cardiovascular disease and nonalcoholic fatty liver disease. Chlorogenic Acids are hypoglycemic agents and can affect lipid metabolism.
CGA is effective in the case of weight gain and fat accumulation by restriction of fat absorption and activation of fat metabolism in the liver.

Antioxidant Benefits

Green Coffee Bean extract is a powerful antioxidant, which helps in averting the damages caused by free radicals. Green coffee is reported to prevent the propagation of cancer cells, thus suggesting that green coffee may have cancer preventing properties as well. Antioxidants also improve skin texture & prevent it from oxidative damage.

Improved Mood and Cognitive Performance

Grecobe, the Green Coffee has recently been launched in the market as ready to drink sachets. It is a single ingredient product without any additives and excipients, thus ensuring better therapeutic value of each sachet. It’s a healthy drink, which is a taste paradise too.

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HEALTH BENEFITS OF GREEN COFFEE BEANS

OXIDATIVE STRESS

Oxidative stress is the disproportion between production of free radicals in the body and ability of the body to detoxify these free radicals with the help of antioxidants present in the body.

Normal molecules in the body have two(paired) electrons in their outer shell. A molecule with a single electron, i.e unpaired, in its outer shell is called a free radical. Thus, free radicals are highlyresponsive molecules, which are produced inside the body by various biochemical reactions. These free radicals are essential to carry out many biological processes such as intracellular killing of bacteria by the phagocytic cells.But when these free radicals start to accumulate inside the body instead of using them up, then they start harming the body cells by targeting lipids, proteins as well as DNA of the cells. This state of harmful effects caused by free radicals is termed as oxidative stress.

(http://www.news-medical.net/health/What-is-Oxidative-Stress.aspx)

DISEASES ASSOCIATED WITH OXIDATIVE STRESS

Oxidative stress is responsible for many diseases inside body. Some of these include:

Neurodegenerative diseases
Parkinson’s disease

Alzheimer’s disease
Huntington’s disease
Lou Gehrig’s disease

Depression
Multiple sclerosis
Cardiovascular disease
Hypoxia
Chronic fatigue syndrome
Age-related development of cancer
Gastric cancer

ANTIOXIDANT

Antioxidants are the molecules that neutralize free radicals by giving them an extra electron.Our body produces antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH) naturally.

These naturally available antioxidants are notsufficient to neutralize all of the free radicals inside the body. As people grow older, this natural production of superoxide dismutase (SOD) and catalase (CAT) cannot keep up with the increasing levels of free radicals. Thus, constant supply of antioxidants either from additional diet or in the form of a drug is necessary for human body.

(http://www.nutrex-hawaii.com/oxidative-stressfree-radicals)

SOURCES OF ANTIOXIDANTS

There are various sources of antioxidants such as Vitamin E, Vitamin C, beta carotene, selenium, phytonutrients, etc. These sources are divided into three categories of antioxidants to fight against oxidative stress. These are:

Natural antioxidants: A human body has its own system of antioxidants which is activated when oxidative stress is originated inside the body. These include superoxide dismutase, catalase and glutathione peroxidase.
Synthetic antioxidants:Another source of antioxidants is synthetic antioxidant which are manufactured by the industries. These antioxidants are in the form of medicines and are available in the market for consumption.
Plant antioxidants: Like us, plants also have antioxidant systems. Various parts of the plants such as fruits, leaves, seeds etc contain bioactive components which can be used as antioxidants for human consumption. These forms of antioxidants are very effective with almost negligible side effects. They are either prepared in the form of extracts or can be consumed along with diet. These include flavonoids, catechins, carotenoids, beta carotene, terpenes, etc.

(http://www.news-medical.net/health/What-are-Antioxidants.aspx)

THERAPEUTIC APPLICATIONS OF ANTIOXIDANTS

Antioxidants in cardiovascular disease: Free radicals produced from LDL are considered to be a major part of cardiovascular events. Antioxidants may inhibit atherosclerosis by targeting LDL associated free radicals and therefore, help to prevent the complications of cardiovascular diseases.

(http://www.sciencedirect.com/science/article/pii/S0140673603136379)

Antioxidants in stroke treatment: Oxidative stress is a potential contributor to strokes. Excessive oxidative stress results in apoptosis, inflammation, DNA damage, lipid per-oxidation and protein denaturation – all of which contribute to and magnify signals leading to damage, followed by stroke. Antioxidants are considered to be a treatment strategy for stroke. They are reported to reduce cell damage caused by stroke by blocking the production of excessive free radicals in the body.

(http://www.webmd.com/stroke/news/20021001/antioxidant-reduces-stroke-damage)

Antioxidants for cancer: There are common antioxidants which are involved in cancer treatment. These are lipoic acid, Vitamin C, beta carotene, Vitamin E, etc. These antioxidants increase the activity of immunity cells against cancer cells. These antioxidants also constrain the damage caused by free radicals to the DNA

(http://www.medicinabiomolecular.com.br/biblioteca/pdfs/Cancer/ca-2346.pdf)

Antioxidants in brain health: Antioxidants are commonly used as treatment for different forms of brain injury. Superoxide dismutase mimetics such as sodium thiopental and propofol are used to treat reperfusion injury and traumatic brain injury.

(http://www.sciencedirect.com/science/article/pii/S1933721309002232)

Antioxidants in neurodegenerative diseases: Neuronal proteins and structural components get altered due to oxidative stress in different neurological disorders leading to neuro-inflammation and loss of cognitive function. Antioxidants are very effective for neuroprotection. Antioxidants target calcium mediated neurotoxicity and prevent the commencement of neurodegenerative diseases. Antioxidants also prevent the oxidation of proteins, lipid peroxidation and prevent the formation of free radicals, therefore acting as a barrier to the oxidative stress.

(Uttara B et al.: Oxidative stress and neurodegenerative diseases: A review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol. 2009 Mar; 7(1): 65–74)

Antioxidants in liver damage: Antioxidants are considered to have the beneficial effects in the management of liver diseases. Clinical study has showed that antioxidants alone or in combination with anti-HCV therapy have shown biochemical efficacy with a decline in serum ALT levels. Antioxidants have proven to be a treatment therapy for alcoholic cirrhosis, alcoholic hepatitis, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.

(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228367/)

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