Early Detection of Insulin Resistance Can Solve PCOS Puzzle
Early Detection of Insulin Resistance Can Solve PCOS Puzzle

Do you wonder what is causing your PCOS?  If you could just identify what is causing it, possibly you could remove the cause and this disease would go away.  Or at least be much easier to manage. 

For the majority of women with polycystic ovary syndrome, a primary cause of symptoms is the presence of a medical condition called “insulin resistance”.  Insulin resistance simply means your cells are “resistant” to or are under-responding to the hormone insulin.  Therefore, insulin cannot efficiently tell the cells to store blood sugar or perform a multitude of other tasks.  The result is that the entire body is thrown into a state of imbalance and distress, leading to weight gain, belly fat, ovulation problems, mood disorders, and skin and hair issues. 

But here’s the tricky part.  Not everyone with PCOS also has insulin resistance — or do they?  It’s estimated that somewhere between 50%-80% of women with polycystic ovarian syndrome have insulin resistance.  But why is there such a wide variation in these estimates?  And how do you know if you have it? 

It may be that part of the problem is in how insulin resistance is defined and how it is measured and diagnosed.  We won’t go into the weeds on this complex issue but let’s cover a couple of high points. 

It’s important to know whether you have insulin resistance because if it’s left unidentified and untreated, the long-term consequences could be disastrous.  You could end up with diabetes, heart disease, cancer, Alzheimer’s or any other degenerative disease. 

As a first step, a doctor can get a pretty good idea of insulin resistance by looking at you, your medical history and some simple blood test results.  For example, if you have a lot of abdominal fat, darkened skin patches, high blood fats and high blood sugar levels, and a family history of diabetes, one might presume you have insulin resistance.  But that’s a presumption.  It would be nice if you could make health decisions based on more than just a presumption. 

So a next step might be to run some additional lab tests, such as an oral glucose tolerance test, hemoglobin A1C or fasting glucose and fasting insulin.  Each of these tests provide useful data points but cannot give you the complete picture you need in order to know whether or not you are developing insulin resistance. 

A few very enterprising health practitioners might order additional lab tests, such as a 24-hour urine test for estrogens, progesterone, androgens (male hormones) and 5-alpha hormone enzyme activity.  If you have PCOS with suspected insulin resistance, this test may show a pattern of high estrogens and androgens, low progesterone and high 5-alpha reductase enzyme.

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