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What Makes Diabetes Painful?

Diabetes can destroy small blood vessels, which in turn can damage the nervous system, and these damaged nerves can cause pain.
The most common forms of diabetes, juvenile and adult onset, can damage many organs and systems. Diabetes can make it hard to digest food, cause heart disease, and destroy small blood vessels, while the nervous system becomes an innocent, injured bystander. The disease’s most common pain syndrome is diabetic neuropathy.
The pain arises from nerves that are injured or malfunctioning. These crippled fibers can be found anywhere along their path, from the tip of the toe to the brain. Diabetes eats away at the thread-thin blood vessels that feed delicate nerve cells.
This is why diabetes pain usually strikes first in the hands and feet. A common pain syndrome from diabetes is described as “stocking and glove” pain because it appears in the hands and feet and usually makes it painful to wear gloves or socks.
Diabetes alters sensation in the smallest nerves, which happen to lie at the end of the peripheral nervous system, in the hands and feet. Diabetes starves these tiny nerves. As a result, the nervous system becomes confused about what is and isn’t painful. Stockings, gloves – anything that touches skin served by these tiny, hypersensitive nerves – is going to send signals to the spinal cord, where they may be mistaken for pain.
Author: Scott Fishman, M. D., Pain Management Specialist

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Taking Insulin for T2 Diabetes Could Expose Patients to Greater Risk of Health Complications

Patients with type 2 diabetes treated with insulin could be exposed to a greater risk of health complications including heart attack, stroke, cancer and eye complications a new study has found.

Examining the UK Clinical Practice Research Datalink (CPRD) – data that characterizes about 10 percent of the UK population – a team of researchers from Cardiff University’s School of Medicine looked at the risk of death for patients taking insulin compared with other treatments designed to lower blood glucose levels in people with type 2 diabetes.

The team’s epidemiological study found people have greater risk of individual complications associated with diabetes such as heart attack, stroke, eye complications and renal disease when compared with patients treated with alternative glucose-lowering treatments.

“Insulin treatment remains the most longstanding blood-glucose-lowering therapies for people with type 2 diabetes, with its use growing markedly in recent years,” according to Professor Craig Currie from Cardiff University’s School of Medicine, who led the study.

“However, with new diabetes therapies and treatments emerging there has been a new spotlight on treatments to ensure what the best and safest form of diabetes treatment is.

“By reviewing data from CPRD between 1999 and 2011 we’ve confirmed there are increased health risks for patients with type 2 diabetes who take insulin to manage their condition,” he adds.

The study adds to previous findings which identified potential health risks of insulin in this specific group of people.

Initial concerns were first raised regarding the use of insulin in type 2 diabetes from a population-based study in Canada, which reported a three-fold increase in mortality.

A similar study of people in UK primary care with type 2 diabetes treated with insulin also reported a 50 percent risk of increased mortality compared with another common treatment regimen.

Professor Currie adds: “Patients currently being treated with insulin should not, under any circumstances, stop taking their medications, and it is important to emphasize that this report related to only type 2 diabetes which typically starts in older people who are overweight.

“Each patient’s individual circumstances are different and treatment decisions are managed by their clinician with all of their medical history fully considered.

“The vast majority of people who take insulin will experience no adverse effects and it remains a reliable and common form of treatment worldwide but this study shows that we need to investigate this matter urgently and the drug regulatory authorities should take interest in this issue.

“Anyone who is concerned should speak to their GP first before taking any action on managing their condition.”

Source: http://jcem.endojournals.org/content/98/2/668.abstract?sid=e5e8ec61-0997-43bd-934b-d4894998abb9

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Diabetes Drug May Affect Thyroid in Some Patients

Medicine tied to lower thyroid-stimulating hormone levels in those with underactive thyroid
WebMD News from HealthDay , By Mary Elizabeth Dallas, HealthDay Reporter

MONDAY, Sept. 22, 2014 (HealthDay News) –Insulin sensitizers commonly used to treat diabetes, may raise the risk of low levels of thyroid-stimulating hormone (TSH) among patients with an under active thyroid, a new study suggests.

The researchers cautioned that low TSH levels may be associated withheartproblems and broken bones, although a cause-and-effect link was not established in this study.

Among those in the study with an underactive thyroid (hypothyroidism), there were 495 incidences of low levels of thyroid-stimulating hormone per year compared with 322 in the normal thyroid group, the report published Sept. 22 in the CMAJ concluded.

Among patients treated for an underactive thyroid, insulin sensitizers were linked with a 55 percent higher risk for low TSH levels, compared to those who were taking sulfonyl urea for their diabetes.

“The results of this longitudinal study confirmed that the use of insulin sensitizers was associated with an increased risk of low TSH levels in patients with treated hypothyroidism,” Dr. Laurent Azoulay, with the department of oncology at McGill University in Montreal, said in a journal news release.

“Given the relatively high incidence of low TSH levels in patients taking insulin sensitizers, it is imperative that future studies assess the clinical consequences of this effect,” Azoulay added.

Two experts agreed that the finding requires further research.

“The question this study poses is: does the suppressed TSH have clinical significance?” said Dr. Gerald Bernstein, director of the diabetes management program at the Friedman Diabetes Institute at Mount Sinai Beth Israel, in New York City.

“The answer is as follows, millions of people have type 2 diabetes and millions of people have low thyroidand take thyroid pills. And given the multiple millions of people who take both drugs there has been no mass clinical issue,” Bernstein said. Also, “this study did not contain any measurements of the two forms of thyroid hormone in the blood. That data might help clarify why the TSH is suppressed.”

Dr. Minisha Sood, an endocrinologist at Lenox Hill Hospital in New York City, added that “the reason for insulin sensitizer’s effect on TSH levels is not clear at present. It is also unclear whether the low TSH levels associated with insulin sensitizers in this study put patients at risk for developing other complications such as cardiovascular diseases.”

Insulin sensitizers are used to lower blood sugar (glucose) levels. It works by reducing glucose production in the liver. To examine the drug’s effect on TSH, the researchers examined data compiled on over 74,000 people who took insulin sensitizers, along with another diabetes drug known as sulfonylurea, over a 25-year period.

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Ways That Doctors Treat Gestational Diabetes

The first step begins with dietary changes

A pregnant woman who is diagnosed as having gestational diabetes is almost always told to monitor her diet. She will probably need to eat differently than she has been eating. Doctors often tell their pregnant patients to eat more small meals throughout the day with a limited number of carbohydrates at each mini meal. The physician may refer the patient to a dietician or nutritionist.

Meeting with a dietician or nutritionist

Diabetes diet plans can be very confusing, so women are usually told to meet with a nurse educator who is knowledgeable in diabetes or with a dietician or nutritionist who can help the woman plan healthy meals. A diabetic diet doesn’t need to be boring or the same every day. It simply requires eating foods that will not cause blood sugar levels to elevate, and a professional is the best one to offer advice on which foods to eat.

Diet during pregnancy is especially important for the diabetic woman

All pregnant women need to eat a healthy diet for the proper development of their baby. Women who develop diabetes during pregnancy need to be aware of proper nutrition as well as keeping their blood sugar levels down at the same time. Most women are told to count carbohydrates and to eat only a certain number of carbs at each meal. They often need to eat more protein, fruits, vegetables, and substitute whole wheat bread for white bread. Basically, a pregnant diabetic woman needs to eat the same type of diet as anyone with Type 2 diabetes, keeping in mind that extra protein may need to be added to the diet. It is important to closely follow the diet that is recommended.

Adding exercise and staying active usually helps control sugar levels

Most women are able to stay active during their pregnancy, and this also applies to women who develop diabetes during this period of their life. How does exercise lower blood sugar? When you exercise, your muscles use some of your body’s glucose for energy. This lowers your blood sugar level. A study by the University of Michigan found that excercise is capable of lowering blood glucose and can be as effective at doing this as a common diabetes medication.

Doctors use other measures when diet and exercise don’t work to improve blood glucose levels

Blood glucose levels that stay high and do not respond to a low carb diet and exercise can be very dangerous to both mother and baby. Doctors usually prescribe insulin injections for pregnant women. Sometimes diabetic medicationis prescribed to lower glucose levels. Fortunately, most women’s diabetes goes away after their baby is born.

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Skin complication- Diabetes

Nerve and blood vessel damage and dehydration from chronic high blood glucosecan cause dry skin problems in people with diabetes. Dry, cracked skin is a potential breeding ground for infection. Staying well-moisturized (both inside and out) and using mild soaps and other gentle skin care products is your best bet for healthy skin. One caveat to moisturizing: make sure that areas such as underarms, groin, and between the toes stay dry to prevent fungal infections.

Other skin conditions associated with diabetes include:

  • Acanthosis nigricans(A-kan-THO-sis NIH-grih-kans) – velvety, light-brown-to-black markings
  • Bullosis diabeticorum (BULL-OH-sis DY-uh-bet-ih-KOR-um) – blisters
  • Diabetic dermopathy – light brown scaly patches
  • Eruptive xanthomatosis (EE-rup-tive zan-thO-mat-Osis) – small yellow bumps ringed with red
  • Necrobiosis Lipoidica Diabeticorum(NEK-roh-by-OH-sis lih-POY-dik-ah DY-uh-bet-ih-KOR-um) – lower leg rash; shiny red with yellow in center
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Diabetic Nerve Problems

Also called: Diabetic neuropathy 

If you have diabetes, your blood sugar levels are too high. Over time, this can damage the covering on your nerves or the blood vessels that bring oxygen to your nerves. Damaged nerves may stop sending messages, or may send messages slowly or at the wrong times.

This damage is called diabetic neuropathy. About half of people with diabetes get it. Symptoms may include

  • Numbness in your hands, legs or feet
  • Shooting pains, burning or tingling
  • Nausea, vomiting, constipation or diarrhea
  • Problems with sexual function
  • Urinary problems
  • Dizziness when you change positions quickly

Controlling your blood sugar can help prevent nerve problems, or keep them from getting worse. Treatment may include pain relief and other medicines.

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Can You Hear Me Now?

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Good Fats, Bad Fats

One type of fat protects your heart, the other puts you at risk for cardiovascular disease. It’s wise to know the difference. 

The body needs certain healthy fats to construct cell membranes, insulate nerves, and ensure that many vitamins, like D and K, work like they’re supposed to.

But not all fats are good for you; some, in the wrong amounts, can seriously damage your health.

Types of Healthy Fats

Dietary fats fall into three categories:

  • Saturated fats.Animals are the primary source of saturated fats, with high levels found in beef and full-fat dairy products and medium levels in poultry and eggs. Some vegetable oils, such as palm oil, also contain a lot of saturated fat.

    Saturated fats are necessary for the body — but in small amounts. Less than 10 percent of your daily calories should come from saturated fats, preferably

    from lean poultry and low-fat or fat-free dairy products. For people who consume 2,000 calories per day, only 20 grams at most should come from saturated

    fat.

  • Unsaturated fats.These good fats are what you should eat the most of as part of a heart-healthy diet. There are two types of unsaturated fats: monounsaturated and polyunsaturated. Pecans, hazelnuts, almonds, sesame seeds, pumpkin seeds, olive oil, peanut oil, and canola oil have high concentrations of monounsaturated fats. Fish, flax seeds, flaxseed oils, corn oil, soybean oil, and sunflower oil contain polyunsaturated fats.

    Omega-3 fatty acids — found in some types of fish like salmon and herring, and in plant products, such as soybean oil, canola oil, walnuts, and flaxseed —

    are a type of polyunsaturated fat that are thought to be particularly good for the heart.

  • Trans fats.These are the fats you may want most but shouldn’t have. Most unsaturated fats are liquid at room temperature. To make them solid, food manufacturers add extra hydrogen, making it a “hydrogenated,” or trans, fat. The highest levels of trans fats are found in baked goods, animal products, and margarine.

Effects of Non-Healthy Fats

Eating a meal high in saturated fats — lots of steak, with potato salad loaded with eggs and mayo — creates the following reaction in the body:

  • Triglyceride (made from excess calories and stored in fat cells) levels go up. High triglyceride levels increase the risk of high blood pressure, diabetes, and heart problems. [8,9]
  • Blood vessels narrow.
  • Blood pressure goes up.
  • LDL levels increase.

And even though trans fats come from vegetable sources, they can cause more heart problems than saturated and unsaturated fats. For this reason many food manufacturing companies and restaurants are no longer using trans fats, and most food labels state their trans fat content.

Good Effects of Fats

Replacing some saturated fat from animal sources with healthy fat from plant sources can reduce LDL and triglyceride levels and your risk of cardiovascular disease.

A recent study found that replacing harmful carbohydrates — found in processed foods like white rice, white bread, and so on — with foods such as nuts and fatty fish, decreases LDL (“bad cholesterol”) levels and increases those of HDL (“good cholesterol”). The researchers also found that eating foods rich in good fat:

  • Lowered blood pressure
  • Reduced heart risks
  • Improved lipid levels

If you’re smart, you’ll opt for unsaturated fats every time.

A Word About Fish

Fish is a heart-healthy source of dietary protein that is low in saturated fat and high in omega-3 fatty acids. It is especially important that postmenopausal women and middle-aged and older men eat the recommended amounts of fish and shellfish (up to 12 ounces per week) to reduce cardiovascular disease risks, according to the American Heart Association (AHA). The AHA cautions that some fish types may be high in environmental pollutants such as mercury and therefore recommends that children and pregnant women avoid fish types that are thought to have the highest mercury levels (for example, king makerel, swordfish, shark, tilefish). The AHA also recommends varying the kinds of fish you eat to minimize effects of these environmental contaminants.

The bottom line is that you need healthy fat in your diet, in limited amounts. And it does matter what kind of fat you eat. For cardiovascular health, limit your intake of saturated fat, avoid trans fat, and make sure most of the fat you eat is good fat from fish, nuts, and healthy oils.

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Fatty liver caused more by obesity than by alcohol now!

 
In our recent post, we made you aware about the various types of liver disease and how they are caused. Extra weight and insulin resistance are bigger risk factors for a fatty liver than moderate amounts of alcohol, warn researchers. It has long been known that large amounts of alcohol can cause fatty liver, which leads to cirrhosis – the most common liver ailment in the western world. However, recently research has shown that obesity and insulin resistance can also cause fatty liver, which in turn is closely associated with diabetes, high blood pressure, and cardiovascular disease. As per research, as little as over a glass of wine for men and just over half a glass of wine per day for women was sufficient to bring about a fatty liver condition, But more recent studies are now showing that moderate amounts of alcohol daily don’t cause fatty liver, reports the journal Annals of Medicine. In their study, 44 individuals participated and were randomized to either abstain entirely from alcohol or drink one glass of red wine per day for women and two glasses for men for three months. Before and after the trial, the subjects provided blood samples, and the fatty content of the liver was measured with state-of-the-art magnetic resonance imaging (MRI).”It turned out that the amount of fat in the liver was linked with obesity and insulin resistance and was almost not at all affected by the red wine. Specifically, after three months, none of the wine drinkers had developed fatty liver or elevated liver transaminases,” liver specialist at the university. What’s more, the harmful LDL cholesterol was 16 percent lower at the end of the study in those who drank red wine compared with total abstainers. ”There is a strong correlation between moderate intake of alcohol and decreased risk of cardiovascular disease”. So, stay away from fatty food, get good exercise and if you drink, stick to moderate amounts for a healthy liver.
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Does Stress Make You Fat?

 
In our recent post, we made you aware about the various types of liver disease and how they are caused. Extra weight and insulin resistance are bigger risk factors for a fatty liver than moderate amounts of alcohol, warn researchers. It has long been known that large amounts of alcohol can cause fatty liver, which leads to cirrhosis – the most common liver ailment in the western world. However, recently research has shown that obesity and insulin resistance can also cause fatty liver, which in turn is closely associated with diabetes, high blood pressure, and cardiovascular disease. As per research, as little as over a glass of wine for men and just over half a glass of wine per day for women was sufficient to bring about a fatty liver condition, But more recent studies are now showing that moderate amounts of alcohol daily don’t cause fatty liver, reports the journal Annals of Medicine. In their study, 44 individuals participated and were randomized to either abstain entirely from alcohol or drink one glass of red wine per day for women and two glasses for men for three months. Before and after the trial, the subjects provided blood samples, and the fatty content of the liver was measured with state-of-the-art magnetic resonance imaging (MRI).”It turned out that the amount of fat in the liver was linked with obesity and insulin resistance and was almost not at all affected by the red wine. Specifically, after three months, none of the wine drinkers had developed fatty liver or elevated liver transaminases,” liver specialist at the university. What’s more, the harmful LDL cholesterol was 16 percent lower at the end of the study in those who drank red wine compared with total abstainers. ”There is a strong correlation between moderate intake of alcohol and decreased risk of cardiovascular disease”. So, stay away from fatty food, get good exercise and if you drink, stick to moderate amounts for a healthy liver.